Investigation of transcriptional changes underlying calcification of aortic valve

Human aortic valve calcification.

To the Editor: Rajamannan et al1 addressed the problem of bone formation in calcified aortic valves, quoting the publication of actual bone formation by Mohler et al.2 Mohler et al had indicated that ossification in calcified aortic valves was relatively common, finding evidence of valve ossification in 36 of 323 patients. Of historical interest, I reported ossification in the left ventricular ...

Aortic valve calcification: a bone of contention

Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on th...

Aortic Valve Calcification and Risk of Stroke

Calcific aortic valve disease: cellular origins of valve calcification.

Calcific aortic valve disease is the most common indication for surgical valve replacement in the world.1 For years this disease was thought to be a passive degenerative phenomenon. Understanding of the cellular mechanisms of this valve lesion will present new cellular therapeutic options to slow disease progression. In this study by Egan et al,2 they identify for the first time in human calcif...

Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve.

AIMS To determine whether mitral annular calcification and aortic valve calcification, with or without stenosis, are expressions of atherosclerotic disease. METHODS The incidence of atherosclerotic risk factors was analysed in patients with mitral annular calcification and aortic valve calcification and in control patients from a prospective echocardiographic database of 8160 consecutive pati...